Several live or alternative studio recordings were previously unreleased. Anthony DeCurtis contributed the liner notes to the album, and The Rolling Stones guitarist Ronnie Wood painted the album's cover. Mitchell Kanner designed the package and, along with Michael Bays, art directed the package. Crossroads was mastered by Greg Calbi and compiled by Bill Levenson. The four-disc box set sold more than four million copies worldwide and was presented with six awards, including two Grammy Awards awarded in 1989. With high commercial success and positive critical response, this is Clapton's most-purchased box set to date.

Disc 1
1. Boom Boom (with The Yardbirds) 2:25
2. Honey in Your Hips (with The Yardbirds) 2:18
3. Baby What's Wrong (with The Yardbirds) 2:40
4. I Wish You Would (with The Yardbirds) 2:19
5. A Certain Girl (with The Yardbirds) 2:17
6. Good Morning Little Schoolgirl (with The Yardbirds) 2:45
7. I Ain't Got You (with The Yardbirds) 1:59
8. For Your Love (with The Yardbirds) 2:29
9. Got to Hurry (with The Yardbirds) 2:35
10. Lonely Years (with John Mayall & the Bluesbreakers) 3:17
11. Bernard Jenkins (with John Mayall & the Bluesbreakers) 3:47
12. Hideaway (with John Mayall & the Bluesbreakers) 3:14
13. All Your Love (with John Mayall & the Bluesbreakers) 3:34
14. Ramblin' On My Mind (with John Mayall & the Bluesbreakers) 3:07
15. Have You Ever Loved a Woman (live) (with John Mayall & the Bluesbreakers) 6:41
16. Wrapping Paper (with Cream) 2:21
17. I Feel Free (with Cream) 2:52
18. Spoonful (with Cream) Dixon 6:30
19. Lawdy Mama (live at the BBC) (with Cream) 1:50
20. Strange Brew (with Cream) 2:46
21. Sunshine of Your Love (with Cream) 4:10
22. Tales of Brave Ulysses (with Cream) 2:46
23. Steppin' Out (live at the BBC) (with Cream) 3:31

Disc 2
1. Anyone for Tennis (with Cream) 2:37
2. White Room (with Cream) 4:56
3. Crossroads (live) (with Cream) 4:14
4. Badge (with Cream) 2:43
5. Presence of the Lord (with Blind Faith) 4:48
6. Can't Find My Way Home (with Blind Faith) 3:15
7. Sleeping in the Ground (with Blind Faith) 2:50
8. Comin' Home (with Delaney & Bonnie & Friends) 3:13
9. Blues Power 3:06
10. After Midnight 3:17
11. Let It Rain 5:01
12. Tell the Truth (with Derek and the Dominos) 3:23
13. Roll It Over (with Derek and the Dominos) 4:29
14. Layla (with Derek and the Dominos) 7:07
15. Mean Old World (with Duane Allman) 3:50
16. Key to the Highway (live) (with Derek and the Dominos) 6:27
17. Crossroads (live) (with Derek and the Dominos) 8:17

Disc 3
1. Got to Get Better in a Little While (with Derek and the Dominos) 5:31
2. Evil (with Derek and the Dominos) 4:25
3. One More Chance (with Derek and the Dominos) 3:17
4. Mean Old Frisco (with Derek and the Dominos) 4:02
5. Snake Lake Blues (with Derek and the Dominos) 3:33
6. Let It Grow 4:56
7. Ain't That Lovin' You 5:26
8. Motherless Children 4:51
9. I Shot the Sheriff (live) 7:48
10. Better Make It Through Today 4:05
11. The Sky Is Crying 3:57
12. I Found a Love 3:38
13. (When Things Go Wrong) It Hurts Me Too 5:34
14. Whatcha Gonna Do 3:01
15. Knockin' on Heaven's Door 4:21
16. Someone Like You 4:30

Disc 4
1. Hello Old Friend 3:34
2. Sign Language (featuring Bob Dylan) 2:56
3. Further on Up the Road (live) 6:18
4. Lay Down Sally 3:50
5. Wonderful Tonight 3:42
6. Cocaine 3:35
7. Promises 3:00
8. If I Don't Be There by Morning 4:34
9. Double Trouble (live) 8:01
10. I Can't Stand It 4:09
11. The Shape You're In 4:09
12. Heaven Is One Step Away 4:09
13. She's Waiting 4:55
14. Too Bad 2:37
15. Miss You 5:05
16. Wanna Make Love to You 5:43
17. After Midnight 4:05

From Polydor's 1988 4 Compaq Disc Edition liner notes (835 261-2)

Disc One
Keith Relf - vocals (1-8), harmonica (1-7)
Eric Clapton - guitar, vocals (14,16,17,19-22)
Chris Dreja - guitar (1-9)
Paul Samwell-Smith - bass (1-9)
Jim McCarty - drums (1-9)
Brian Auger - harpsichord (8)
Denny Piercey - bongos (8)
John Mayall - vocals (10,13,15), harmonica (10), piano (11,14), organ (12,13,15)
John McVie - bass (12-14)
Hughie Flint - drums (12-15)
Jack Bruce - bass (15-23), vocals (16-18,20-22), piano (16,17)
Ginger Baker - drums (16-23), vocals (16,17)

Disc Two
Eric Clapton - vocals (1,3,4,9-17), guitar (1-7,9-17), lead guitar (8)
Jack Bruce - bass (1-4), vocals (2)
Ginger Baker - drums (1-7), percussion (1), tympani (2)
Felix Pappalardi - viola (1,2), mellotron (1,4), piano (4)
George Harrison - guitar (4,13), vocals (13)
Steve Winwood - vocals (5-7), piano (5,7), bass (5), guitar (6)
Rick Grech - bass (6,7)
Delaney Bramlett - vocals (8-11), guitar (8-11)
Bonnie Bramlett - vocals (8-11)
Dave Mason - guitar (8,13), vocals (13)
Bobby Whitlock - keyboards (8,9), organ (10,11,14), guitar (12), vocals (12-14), piano (13,14,16,17)
Carl Radle - bass (8-14,16,17)
Jim Gordon - drums (8-14,16,17), piano (14)
Jim Price - trumpet (8-11)
Bobby Keys - sax (8-11)
Tex Johnson - percussion (8)
Rita Coolidge - vocals (8-11)
Leon Russell - piano (9-11)
Sonny Curtis - vocals (9-11)
Jerry Allison - vocals (9-11)
Stephen Stills - guitar (11), vocals (11)
Duane Allman - guitar (14,15)

Disc Three
Eric Clapton - vocals (1-4,6-16), guitar, dobro (6)
Carl Radle - bass
Jim Gordon - drums (1-5)
Bobby Whitlock - piano (2-5)
George Terry - guitar (6,8-16), vocals (6)
Dick Sims - organ (6-11,13-16), piano (12)
Albhy Galuten - piano (6,8), ARP synthesizer (6)
Jamie Oldaker - drums (6-16)
Yvonne Elliman - vocals (6,7,9,13-16)
Tom Bernfeld - vocals (6)
Dave Mason - guitar (7)
Marcy Levy - vocals (9,14-16), tambourine (9)
Peter Tosh - vocals (14), guitar (14)

Disc Four
Eric Clapton - vocals, guitar, dobro (2)
George Terry - guitar (1-8)
Jesse Ed Davis - guitar (1,2)
Dick Sims - keyboards (1-8)
Carl Radle - bass (1-8)
Jamie Oldaker - drums (1-8,12,13)
Yvonne Elliman - vocals (1,3-6)
Marcy Levi - vocals (1,3-8,12,13)
Sergio Pastora Rodriguez - percussion (1-3)
Bob Dylan - vocals (2)
Robbie Robertson - guitar (2)
Ron Wood - guitar (2)
Albert Lee - guitar (9-11), keyboards (11), vocals (11)
Chris Stainton - keyboards (9,10,12,14), synthesizer and Hammond organ (13)
Dave Markee - bass (9,10)
Henry Spinetti - drums (9,10)
Gary Brooker - keyboards (10)
Ry Cooder - guitar (11)
Donald "Duck" Dunn - bass (11-14)
Roger Hawkins - drums (11)
John Sambataro - vocals (11)
Chuck Kirkpatrick - vocals (11)
Peter Robinson - synthesizer (12,13)
Phil Collins - percussion (12,15,16), Simmons and snare drums (13), drums (14-16), vocals (15,16)
Ray Cooper - percussion (12,13)
Shaun Murphy - vocals (12,13)
Greg Phillinganes - keyboards (15,16), vocals (15,16)
Nathan East - bass (15-17), vocals (17)
Michael Brecker - sax (15)
Jon Faddis - trumpet (15)
Randy Brecker - trumpet (15)
Dave Bargeron - trombone (15)
Katie Kissoon - vocals (16)
Tessa Niles - vocals (16)
Alan Clark - keyboards (17)
Andy Newmark - drums (17)